FHA domain-ligand interactions: importance of integrating chemical and biological approaches.
نویسندگان
چکیده
Combinatorial library screens based on binding affinity may preferentially select ligands with ability for ionic interactions and miss the biologically relevant ligands that bind more weakly with predominantly hydrophobic interactions.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 127 42 شماره
صفحات -
تاریخ انتشار 2005